Cancer and its treatment result in severe biochemical and physiological alterations associated with a deterioration of QoL. These metabolic changes lead to decreased food intake and promote wasting. Cancer-related malnutrition can evolve to cancer cachexia due to complex interactions between pro-inflammatory cytokines and host metabolism. Beside and beyond the adjuvant nutritional intervention in cancer pdf physical and the metabolic effects of cancer, patients often suffer as well from psychological distress, including depression.
Such an approach, which should be started as early as possible, can reduce or even reverse their poor nutritional status, improve their performance status and consequently their QoL. Nutritional intervention accompanying curative treatment has an additional and specific role, which is to increase the tolerance and response to the oncology treatment, decrease the rate of complications and possibly reduce morbidity by optimizing the balance between energy expenditure and food intake. In palliative care, nutritional support aims at improving patient’s QoL by controlling symptoms such as nausea, vomiting and pain related to food intake and postponing loss of autonomy. The literature review supports that nutritional care should be integrated into the global oncology care because of its significant contribution to QoL. Furthermore, the assessment of QoL should be part of the evaluation of any nutritional support to optimize its adequacy to the patient’s needs and expectations. Check if you have access through your login credentials or your institution.
2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. It has also been proposed that cancer cells increase glucose and hydroperoxide metabolism to compensate for increased levels of ROS. Given this theoretical construct, it is reasonable to propose that forcing cancer cells to use mitochondrial oxidative metabolism by feeding ketogenic diets that are high in fats and low in glucose and other carbohydrates, would selectively cause metabolic oxidative stress in cancer versus normal cells. Increased metabolic oxidative stress in cancer cells would in turn be predicted to selectively sensitize cancer cells to conventional radiation and chemotherapies. This review summarizes the evidence supporting the hypothesis that ketogenic diets may be safely used as an adjuvant therapy to conventional radiation and chemotherapies and discusses the proposed mechanisms by which ketogenic diets may enhance cancer cell therapeutic responses. Authors made equal contributions to manuscript. Looking for online definition of disease in the Medical Dictionary?
Meaning of disease medical term. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. An interruption, cessation, or disorder of a body, system, or organ structure or function. The corresponding lesion on the glans penis is termed erythroplasia of Queyrat. Cushing’s syndrome in which the hyperadrenocorticism is secondary to excessive pituitary secretion of adrenocorticotropic hormone. In the congenital form, there is hepatosplenomegaly with cirrhosis, and microcephaly with mental or motor retardation. Acquired disease may cause a clinical state similar to infectious mononucleosis.
When acquired by blood transfusion, postperfusion syndrome results. Ebola virus, seen in the Sudan and Zaire. X-linked lysosomal storage disease of glycosphingolipid catabolism resulting from deficiency of α-galactosidase A and leading to accumulation of ceramide trihexoside in the cardiovascular and renal systems. Gaucher’s cells in the marrow, and by hepatosplenomegaly and erosion of the cortices of long bones and pelvis.
1,4,-glucosidase, the severe infant form resulting in generalized glycogen accumulation, with cardiomegaly, cardiorespiratory failure, and death, and a milder adult form being a gradual skeletal myopathy that sometimes causes respiratory problems. II, VII, IX, and X. Reed-Sternberg cells are characteristically present. Four types have been distinguished on the basis of histopathologic criteria.
X-linked hypophosphatemia, similarly due to a defect in renal tubular function but usually showing osteomalacia without radiographic evidence of rickets. Crohn’s disease and ulcerative colitis. It is often associated with vasculitis of the large coronary vessels. Kyasanur Forest of India, communicable to humans, in whom it produces hemorrhagic symptoms. If untreated it is rapidly fatal. Marburg, Germany, among laboratory workers exposed to African green monkeys. X-linked disorder consisting of bilateral blindness from retinal malformation, mental retardation, and deafness.